I-100CM encinci ye-Sex Doll yabadala

Umthamo wentsholongwane egazini ophezulu

I-Delta ayisuleleki ngakumbi kuneeyantlukwano zangaphambili ze-SARS-CoV-2, inokubangela isifo esiqatha. Abantu abosulelwe lizibuko le-Delta elahlukileyo liphindaphindwe kangange-1,000 inani leentsholongwane zentsholongwane (ezibizwa iingcali ngokuba “ngumthamo wentsholongwane egazini”) kwi-swab yeempumlo zabo xa kuthelekiswa nabo bosulelwe kolunye uhlobo, “olunyuke kakhulu,” utshilo u-Eric Topol, umseki kunye nomlawuli we-Scripps Research Translational Institute, owayengabandakanyekanga kolu phononongo.

Esinye isizathu soku kukuba ukwahluka kweDelta kuphindaphinda ngokukhawuleza empumlweni. Uphononongo, olungekaphononongwa ngoontanga lubonise ukuba ukwahluka kweDelta kuthathe umndilili weentsuku ezine ukufikelela kumanqanaba abonakalayo emva kokuba sesichengeni somntu ogulayo, xa kuthelekiswa neentsuku ezintandathu zentsholongwane kaWuhan.

Nasemva kogonyo, usulelo lweDelta luvelise umthamo wentsholongwane egazini ophindwe kayi-10 kunosulelo olungelulo olwaseDelta. Enyanisweni amaphononongo aliqela akutsha nje, akukho ntanga eye yaphononongwa okwangoku, abonisa ukuba abantu abagonyiweyo banomthamo wentsholongwane egazini ofanayo nalowo ungagonywanga. “Sibona usulelo kwaye sibona inani elikhulu labantu abosulelwa lityala elinye, elixhalabisa kakhulu. Kuthetha ukuba intsholongwane isosulela kakhulu kwaye iyakwazi ukunqanda ... ukugonya okubangelwa kugonyo, utshilo uRavindra Gupta, isazi sebhayoloji yeklinikhi kwiYunivesithi yaseCambridge, okhokele kuphononongo olungekaphononongwa ngoontanga.

I-Delta ikwangcono ekutshabalaliseni iiseli ngenxa yoguquko olukwindawo engama-681 yeprotein yayo ye-spike, ekhawuleza ixhaphake kwezinye izinto ezahlukeneyo kwihlabathi jikelele kwaye kucingelwa ukuba yinguqu yomdlalo. Olu tshintsho lwe-P681R lwenza kube lula kwiDelta kunye nokwahluka okunxulumene neKappa ukuhlasela iseli yomkhosi ngokudibanisa iiseli ezosulelekileyo kwizakhiwo ezibizwa ngokuba yi-syncytium, eyindlela yokukhawulezisa usulelo. I-Syncytia nayo yenziwa zezinye iintsholongwane ezifana ne-HIV. "Sifumene kuvavanyo lwenkcubeko yeeseli ukuba ukwahluka kweDelta kubonisa i-syncytia enkulu xa kuthelekiswa ne-SARS-CoV-2," ucacisile uKei Sato, ugqirha wentsholongwane kwiYunivesithi yaseTokyo, eJapan.

Ukwahluka kweDelta kwakhona kuye kwenzeka iinguqulelo ezininzi kwiprotein yayo ye-spike ebonakala ngathi iphucula amandla entsholongwane okubophelela kwi-ACE2 receptor kwaye iphephe impendulo yamajoni omzimba.